Back to Search
Start Over
(R)-(−)-Xanthorrhizol Inhibits the Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Matrix Metalloproteinases via the NF- κ B Signaling Pathway.
- Source :
-
Planta Medica . Aug2024, Vol. 90 Issue 10, p785-791. 7p. - Publication Year :
- 2024
-
Abstract
- (R)-(−)-xanthorrhizol is a bioactive sesquiterpenoid and major chemical constituent of Curcuma zanthorrhiza rhizomes. It was reported to have many pharmacological activities including nephroprotective, hepatoprotective, antimicrobial, anti-inflammatory, antioxidant, antihypertensive, antihyperglycemic, antiplatelet, estrogenic, and antiestrogenic properties. (R)-(−)-xanthorrhizol was also investigated for antiproliferative activity against many cancer cells including breast, lung, liver, ovarian, and colon cancer. It was also revealed to have a potential effect on TNBC cells MDA-MB-231. Considering the previous studies, this study has aimed to investigate the antimigratory and anti-invasive properties, as well as the possible molecular mechanisms, behind these properties. The findings of (R)-(−)-xanthorrhizol on MDA-MB-231 cell migration and invasion demonstrated significant inhibition at three different concentrations in a concentration-dependent manner, which was observed in the scratch, transwell migration, and invasion assays. Further investigation of the molecular mechanism using gelatin zymography revealed that (R)-(−)-xanthorrhizol prevented cell migration and invasion of breast cancer cells through the inhibition of matrix metalloproteinase-2 and matrix metalloproteinase-9 expression. Western blot analysis indicated that the inhibition of matrix metalloproteinases is possibly the result of the inhibition of phosphorylation in the NF- κ B signaling pathway. These findings corroborate (R)-(−)-xanthorrhizol to proceed for the further studies as a possible future drug candidate for cancer patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of antineoplastic agents
*NF-kappa B
*PHOSPHORYLATION
*BREAST tumors
*CANCER patient medical care
*CELL motility
*CELLULAR signal transduction
*DESCRIPTIVE statistics
*CELL lines
*PLANT extracts
*CURCUMIN
*MATRIX metalloproteinases
*MEDICINAL plants
*MOLECULAR structure
*WESTERN immunoblotting
*PHENOLS
*WOMEN'S health
Subjects
Details
- Language :
- English
- ISSN :
- 00320943
- Volume :
- 90
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Planta Medica
- Publication Type :
- Periodical
- Accession number :
- 178834120
- Full Text :
- https://doi.org/10.1055/a-2339-2633