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Vitamin D deficiency and the risk of diabetic retinopathy in patients with type 2 diabetes in Tibet: a cross-sectional analysis.
- Source :
-
BMC Endocrine Disorders . 8/2/2024, Vol. 24 Issue 1, p1-9. 9p. - Publication Year :
- 2024
-
Abstract
- Background: Diabetic retinopathy (DR) is one of the most common complications of diabetes worldwide. The aim of this study was to assess the prevalence of DR in hospitalized patients with type 2 diabetes (T2DM) in Tibet and to identify risk factors that may influence the occurrence of DR. Methods: This was a cross-sectional study conducted in a third-class hospital in the Tibet Autonomous Region. The prevalence of DR in hospitalized patients with T2DM was measured. Univariate and multivariate logistic regression, restricted cubic spline (RCS) analysis and receiver-operating characteristic curve analysis were used to investigate the risk factors for DR. Results: The prevalence of DR was 29.3%. The duration of diabetes; concentrations of 25-OH-VitD3, hemoglobin, fasting insulin, alanine aminotransferase, total bilirubin, and creatinine; and HOMA-IR were significantly different between DR patients and non-DR patients (all P < 0.05). Univariate and multivariate logistic regression revealed that a longer duration of diabetes and lower 25-OH-VitD3 levels were associated with increased DR risk. RCS analysis suggested overall positive associations of the duration of diabetes and 25-OH-VitD3 concentrations with DR risk (P nonlinearity < 0.05). The turning points for the duration of diabetes and 25-OH-VitD3 concentrations were 5.1 years and 10.6 ng/mL, respectively. The sensitivity, specificity, and area under the receiver-operating characteristic curve for the combination of the duration of diabetes and 25-OH-VitD3 levels were 79.4%, 69.4% and 0.764, respectively. Conclusions: Given the high prevalence of DR in hospitalized patients with T2DM in Tibet, vitamin D supplementation seems to be important in the prevention of DR to some degree. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VITAMIN D deficiency
*RISK assessment
*CROSS-sectional method
*PEARSON correlation (Statistics)
*RECEIVER operating characteristic curves
*DISEASE duration
*CREATININE
*T-test (Statistics)
*STATISTICAL significance
*RESEARCH funding
*DIABETIC retinopathy
*HOSPITAL care
*MULTIPLE regression analysis
*HEMOGLOBINS
*DISEASE prevalence
*MULTIVARIATE analysis
*INSULIN
*BILIRUBIN
*MANN Whitney U Test
*CHI-squared test
*DESCRIPTIVE statistics
*INSULIN resistance
*TYPE 2 diabetes
*STATISTICS
*ALANINE aminotransferase
*DATA analysis software
*VITAMIN D
*FASTING
*SENSITIVITY & specificity (Statistics)
*DISEASE risk factors
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 14726823
- Volume :
- 24
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Endocrine Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 178807186
- Full Text :
- https://doi.org/10.1186/s12902-024-01668-4