2006—2020年中国丙型病毒性肝炎发病趋势及年龄-时期-队列分析.

Objective To analyze the incidence trend of viral hepatitis C (HCV) in China from 2006 to 2020, and to explore the influence of age, period and birth cohort on the incidence of HCV. Methods The data of hepatitis C cases and demographic data were collected in China from 2006 to 2020. The Joinpoint regression model was applied to analyze the trend of the incidence of hepatitis C in the whole population and by age group. The age-period-cohort model was applied to explore the effects of age, period and birth cohort on the incidence. Results The incidence of hepatitis C increased from 2006 to 2020, and the average incidence was 12.82 per 100 000. Unlike other age groups, the incidence of hepatitis C in people age group 60 and above still showed an upward trend from 2010 to 2018 (APC=3.40). The time of onset effect of hepatitis C increased from 0.63 (95%CI: 0.77-0.70) during 2006-2010 to 0.92 (95%CI: 0.84-1.00) during 2016 to 2020. The birth cohort effect was lowest in the 1926-1930 cohort and peaked in the 1991-1995 cohort (RR=1.41, 95%CI: 1.01-1.97). Conclusion The incidence of hepatitis C increased during the study period, and the disease burden increased with age. High-risk groups should be regularly screened and monitored. [ABSTRACT FROM AUTHOR]