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Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4+ T Cells.
- Source :
-
Journal of Infectious Diseases . 7/15/2024, Vol. 230 Issue 1, pe43-e47. 5p. - Publication Year :
- 2024
-
Abstract
- Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis –enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4+ T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV
*T cells
*PREVOTELLA
*DYSBIOSIS
*CD4 antigen
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 230
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 178738687
- Full Text :
- https://doi.org/10.1093/infdis/jiae166