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Anaphylaxis and desensitization differently activate and induce IL‐8 release by mast cells in a human peanut allergy in vitro model.

Authors :
Tontini, Chiara
Bahri, Rajia
Simpson, Angela
Bulfone‐Paus, Silvia
Source :
Allergy. Aug2024, Vol. 79 Issue 8, p2289-2292. 4p.
Publication Year :
2024

Abstract

This article explores the differences in mast cell activation between anaphylaxis and desensitization in human peanut allergy. The study used human mast cells and sera from peanut-allergic individuals to investigate the functional differences in mast cell activation after anaphylaxis and desensitization. The findings suggest that desensitization reduces the overall activation and release of interleukin 8 (IL-8) compared to anaphylaxis. The study also found that refractoriness, or temporary antigen-specific resistance, occurs independently of the initial activation modality. Further research is needed to understand the immune response to allergen-specific immunotherapy in vivo. [Extracted from the article]

Details

Language :
English
ISSN :
01054538
Volume :
79
Issue :
8
Database :
Academic Search Index
Journal :
Allergy
Publication Type :
Academic Journal
Accession number :
178737802
Full Text :
https://doi.org/10.1111/all.16222