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Anaphylaxis and desensitization differently activate and induce IL‐8 release by mast cells in a human peanut allergy in vitro model.
- Source :
-
Allergy . Aug2024, Vol. 79 Issue 8, p2289-2292. 4p. - Publication Year :
- 2024
-
Abstract
- This article explores the differences in mast cell activation between anaphylaxis and desensitization in human peanut allergy. The study used human mast cells and sera from peanut-allergic individuals to investigate the functional differences in mast cell activation after anaphylaxis and desensitization. The findings suggest that desensitization reduces the overall activation and release of interleukin 8 (IL-8) compared to anaphylaxis. The study also found that refractoriness, or temporary antigen-specific resistance, occurs independently of the initial activation modality. Further research is needed to understand the immune response to allergen-specific immunotherapy in vivo. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 01054538
- Volume :
- 79
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 178737802
- Full Text :
- https://doi.org/10.1111/all.16222