Pustulosis exantemática generalizada aguda de presentación atípica con lesiones tipo vasculitis.

Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction, typically characterized by the appearance of multiple pinpoint non-follicular pustules, less than 5 mm, sterile, on an erythematous-edematous base, and can be disseminated. Up to 90% of cases are associated with drug administration. It usually resolves in less than 15 days with a good prognosis. We describe the case of a 31-year-old man who experienced drug-induced AGEP with multisystem involvement. However, at the onset, he presented with purpuric lesions on the skin and oral mucosal involvement, leading to the consideration of other differential diagnoses. The clinical evolution, including pustule formation and histopathological findings, led to the diagnosis of AGEP. He received standard supportive care, including topical and systemic corticosteroids, with a favorable clinical outcome. This case highlights an atypical presentation of AGEP and the possibility of overlap with other drug adverse reactions, emphasizing the need for timely and accurate diagnosis and management. [ABSTRACT FROM AUTHOR]