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Analysis of Virus-Specific B Cell Epitopes Reveals Extensive Antigen Degradation Prior to Recognition.
- Source :
-
Cells (2073-4409) . Jul2024, Vol. 13 Issue 13, p1076. 11p. - Publication Year :
- 2024
-
Abstract
- B cell epitopes must be visible for recognition by cognate B cells and/or antibodies. Here, we studied that premise for known linear B cell epitopes that were collected from the Immune Epitope Database as being recognized by humans during microbial infections. We found that the majority of such known B cell epitopes are virus-specific linear B cell epitopes (87.96%), and most are located in antigens that remain enclosed in host cells and/or virus particles, preventing antibody recognition (18,832 out of 29,225 epitopes). Moreover, we estimated that only a minority (32.72%) of the virus-specific linear B cell epitopes that are found in exposed viral regions (e.g., the ectodomains of envelope proteins) are solvent accessible on intact antigens. Hence, we conclude that ample degradation/processing of viral particles and/or infected cells must occur prior to B cell recognition, thus shaping the B cell epitope repertoire. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELLULAR recognition
*CELL morphology
*EPITOPES
*DATABASES
*ANTIGENS
*B cells
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 13
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Cells (2073-4409)
- Publication Type :
- Academic Journal
- Accession number :
- 178692929
- Full Text :
- https://doi.org/10.3390/cells13131076