Back to Search
Start Over
Evaluation of Anticancer Activity of Nucleoside–Nitric Oxide Photo-Donor Hybrids.
- Source :
-
Molecules . Jul2024, Vol. 29 Issue 14, p3383. 19p. - Publication Year :
- 2024
-
Abstract
- Herein, we report the synthesis of a new hybrid compound based on a 2′-deoxyuridine nucleoside conjugated with a NO photo-donor moiety (dU-t-NO) via CuAAC click chemistry. Hybrid dU-t-NO, as well as two previously reported 2′-deoxyadenosine based hybrids (dAdo-S-NO and dAdo-t-NO), were evaluated for their cytotoxic and cytostatic activities in selected cancer cell lines. dAdo-S-NO and dAdo-t-NO hybrids displayed higher activity with respect to dU-t-NO. All hybrids showed effective release of NO in the micromolar range. The photochemical behavior of the newly reported hybrid, dU-t-NO, was studied in the RKO colon carcinoma cell line, whereas the dAdo-t-NO hybrid was tested in both colon carcinoma RKO and hepatocarcinoma Hep 3B2.1-7 cell lines to evaluate the potential effect of NO released upon irradiation on cell viability. A customized irradiation apparatus for in vitro experiments was also designed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CLICK chemistry
*CELL lines
*ANTINEOPLASTIC agents
*CELL survival
*NITRIC oxide
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 29
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 178690389
- Full Text :
- https://doi.org/10.3390/molecules29143383