FURNA: A database for functional annotations of RNA structures.

Despite the increasing number of 3D RNA structures in the Protein Data Bank, the majority of experimental RNA structures lack thorough functional annotations. As the significance of the functional roles played by noncoding RNAs becomes increasingly apparent, comprehensive annotation of RNA function is becoming a pressing concern. In response to this need, we have developed FURNA (Functions of RNAs), the first database for experimental RNA structures that aims to provide a comprehensive repository of high-quality functional annotations. These include Gene Ontology terms, Enzyme Commission numbers, ligand-binding sites, RNA families, protein-binding motifs, and cross-references to related databases. FURNA is available at https://seq2fun.dcmb.med.umich.edu/furna/ to enable quick discovery of RNA functions from their structures and sequences. There is an increasing number of experimentally determined 3D RNA structures, but the majority lack functional annotation. To address this gap, this study provides a database of 3D RNA structures with comprehensive, high-quality functional annotations to enable discovery of RNA functions from structural and sequence information [ABSTRACT FROM AUTHOR]