Design and Modeling of a Novel Highly Sensitive Surface Plasmon Resonance Sensor Applying Tin Selenide and Graphene for Cancer Detection.

A novel design of an optical biosensor based on surface plasmon resonance using tin selenide (SnSe) and graphene is presented. Including biological solutions, the performance of the obtained biosensor over a wide range of refractive index variations is promising. It is designed such that its key parameters are optimized to detect different cancerous cells with high selectivity and sensing ability. The design and analysis of the sensor have been carried out by implementing a finite element method–based simulation platform. The results revealed that the designed sensor can provide a sensitivity of 121.0 deg.RIU−1, 134.2 deg.RIU−1, 142.9 deg.RIU−1, 143.6 deg.RIU−1, and 72.2 deg.RIU−1 for sensing skin, cervical, blood, adrenal gland, and breast cancerous cells respectively with maximum quality factor of 408 RIU−1 and a detection accuracy of 5.71. The results obtained using the proposed model of the SPR biosensor are promising. It could be a potential candidate for several sensing applications such as detecting different types of cancer disease in the early stages. Such detection is anticipated to save the lives of cancer patients. Comparing our results to work published recently, we were able to achieve an enhanced angular sensitivity (S) ranging from 72 to 143.6 deg.RIU−1, a detection accuracy (DA) ranging from 2.66 to 5.71, and a quality factor (QF) ranging from 190 to 408 RIU−1. [ABSTRACT FROM AUTHOR]