Plasenta Previada Birinci Trimester Tam Kan Sayımı İnflamatuar İndekslerinin Değerlendirilmesi.

Aim: To evaluate systemic inflammation in pregnant women diagnosed with placenta previa (PP). First-trimester complete blood count indices of PP patients were assessed. Materials and Method: This cross-sectional study was conducted with 346 singleton pregnant women, including 115 PP cases (study group) and 231 healthy pregnant women (control group) who were operated on in a tertiary center for one year. The study group was then divided into two subgroups. Those who underwent peripartum hysterectomy due to placenta accreta spectrum (PAS) were determined as PAS-positive, and those without invasion were PAS-negative. Demographic and obstetric characteristics laboratory results were recorded retrospectively. Systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) values were calculated. Data were compared using the independent sample t-test and presented as mean and standard deviation. Results: The mean value of maternal age, body mass index, and gestational weeks at which hemograms were evaluated were similar between the study and control groups. While white blood cell and neutrophil counts were significantly higher in the PP group, red blood cell and hemoglobin counts were lower (p<0.001). The mean values of SII and SIRI of the PP group were found to be significantly higher than the healthy pregnant women [(1266±846 x10/L and 892±479 x10/L, respectively) and (2±1.2 x10/L and 1.3±0.7 x10/L, respectively) (p<0.001)]. Although SII and SIRI were higher in the PAS-positive group than the PAS-negative group, no statistical difference was found. Conclusion: Evaluation of inflammation is important for PP cases. In addition to other methods, easily accessible laboratory indices can be used to manage high-risk pregnancies. [ABSTRACT FROM AUTHOR]