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The Emerging Role of Natural Products in Cancer Treatment.

Authors :
Ghosh, Sumit
Das, Sanjib Kumar
Sinha, Krishnendu
Ghosh, Biswatosh
Sen, Koushik
Ghosh, Nabanita
Sil, Parames C.
Source :
Archives of Toxicology. Aug2024, Vol. 98 Issue 8, p2353-2391. 39p.
Publication Year :
2024

Abstract

The exploration of natural products as potential agents for cancer treatment has garnered significant attention in recent years. In this comprehensive review, we delve into the diverse array of natural compounds, including alkaloids, carbohydrates, flavonoids, lignans, polyketides, saponins, tannins, and terpenoids, highlighting their emerging roles in cancer therapy. These compounds, derived from various botanical sources, exhibit a wide range of mechanisms of action, targeting critical pathways involved in cancer progression such as cell proliferation, apoptosis, angiogenesis, and metastasis. Through a meticulous examination of preclinical and clinical studies, we provide insights into the therapeutic potential of these natural products across different cancer types. Furthermore, we discuss the advantages and challenges associated with their use in cancer treatment, emphasizing the need for further research to optimize their efficacy, pharmacokinetics, and delivery methods. Overall, this review underscores the importance of natural products in advancing cancer therapeutics and paves the way for future investigations into their clinical applications. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03405761
Volume :
98
Issue :
8
Database :
Academic Search Index
Journal :
Archives of Toxicology
Publication Type :
Academic Journal
Accession number :
178655302
Full Text :
https://doi.org/10.1007/s00204-024-03786-3