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Synthesis and Structure of Cytotoxic Copper(II) Complexes Based on di(o-tolyl)Phosphinic Acid and 2,2'-Bipyridine/1,10-Phenanthroline.
- Source :
-
Journal of Structural Chemistry . Jul2024, Vol. 65 Issue 7, p1465-1476. 12p. - Publication Year :
- 2024
-
Abstract
- The following series of copper(II) complexes based on di(o-tolyl)phosphinic acid (HL) and 1,10-phenanthroline (phen), 5-chloro-1,10-phenanthroline (Cl-phen), 4,7-dimethyl-1,10-phenanthroline (dmphen), 2,2ā²-bipyridine (bipy) is prepared and characterized: [Cu(OH)L]n (1), [Cu(phen)(H2O)L2] (2), [Cu(dmphen)(H2O)L2] (3), [Cu(Cl-phen)(H2O)L2] (4), [Cu(bipy)(H2O)L2] (5). According to the XRD data, the phosphinate anion Lā exhibits a monodentate coordination in mononuclear complexes 2ā5 and a bidentate-bridge coordination in the polymer complex 1. The cytotoxic activity of the ligands and complexes is studied using the A549 (carcinoma) and MRC5 (non-neoplastic fibroblasts) human lung cell lines. It is shown that the complexes exhibit pronounced dose-dependent cytotoxicity to these cell lines in the 1-50 µM concentration range. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00224766
- Volume :
- 65
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Structural Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 178655120
- Full Text :
- https://doi.org/10.1134/S0022476624070175