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Activin A: a marker of mineral bone disorder in children with chronic kidney disease?
- Source :
-
Pediatric Nephrology . Sep2024, Vol. 39 Issue 9, p2773-2777. 5p. - Publication Year :
- 2024
-
Abstract
- Background: Activin A has been shown to enhance osteoclast activity and its inhibition results in bone growth. The potential role of activin A as a marker of chronic kidney disease-mineral bone disease (CKD-MBD) and its relationship with other markers has not been studied in children with CKD. Methods: A cross sectional study was conducted among 40 children aged 2 to 18 years with CKD (Stage 2 to 5; 10 in each stage) and 40 matched controls. Activin A, cathepsin K, FGF-23, PTH, serum calcium, phosphorous and alkaline phosphatase in both groups were measured and compared. The correlation of activin A and markers of CKD-MBD was studied. A p value of < 0.05 was considered significant. Results: The mean age of children with CKD was 9.30 ± 3.64 years. Mean levels of activin A in cases were 485.55 pg/ml compared to 76.19 pg/ml in controls (p < 0.001). FGF-23 levels in cases were 133.18 pg/ml while in controls it was 6.93 pg/ml (p < 0.001). Mean levels of cathepsin K were also significantly higher in cases as compared to controls. There was a progressive increase in activin A and cathepsin K levels with increasing stage of CKD. Activin A had a significant positive correlation with serum creatinine (r = 0.51; p < 0.001). Conclusions: Activin A levels progressively rise with advancing CKD stage. These findings suggest that activin A can be a potential early marker of CKD-MBD in children. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OSTEOPENIA
*CROSS-sectional method
*PHOSPHORUS
*CREATININE
*DATA analysis
*SCIENTIFIC observation
*SAMPLE size (Statistics)
*HEMOGLOBINS
*PEPTIDE hormones
*ALKALINE phosphatase
*DESCRIPTIVE statistics
*CHI-squared test
*AGE distribution
*PARATHYROID hormone
*CALCIUM
*PROTEOLYTIC enzymes
*FIBROBLAST growth factors
*STATISTICS
*MINERALS
*COMPARATIVE studies
*BIOMARKERS
CHRONIC kidney failure complications
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 39
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Pediatric Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 178622919
- Full Text :
- https://doi.org/10.1007/s00467-024-06400-x