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Electrochemical Oxidative Cross-Coupling for the Construction of C(sp3)–C(sp3) Bonds.

Authors :
Wen, Kang-Min
Chang, Xi-Hao
Guo, Chang
Source :
Synthesis. Aug2024, Vol. 56 Issue 16, p2572-2580. 9p.
Publication Year :
2024

Abstract

A highly effective oxidation cross-coupling method involving para -cresol derivatives and malononitrile derivatives has been developed utilizing undivided electrolytic conditions. This electrochemical approach offers a robust route for synthesizing diverse malononitrile derivatives featuring quaternary carbon centers and incorporating para -phenol groups. Notably, the direct electrooxidation of the C(sp3)–H bond in the para -cresol derivative plays a crucial role in this process under electrolytic conditions. Various para -cresol derivatives and malononitrile derivatives with different substituents are readily compatible with this electrochemical transformation, affording coupling compounds in up to 99% yield. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*MALONONITRILE

Details

Language :
English
ISSN :
00397881
Volume :
56
Issue :
16
Database :
Academic Search Index
Journal :
Synthesis
Publication Type :
Academic Journal
Accession number :
178620984
Full Text :
https://doi.org/10.1055/a-2309-1501