Особливості клінічного перебігу та якості життя у пацієнтів з хронічним панкреатитом та гастродуоденальними змінами

Despite the significant progress in the study of pancreatic gland (PG) pathology, the clinical symptoms and syndromes, as well as assessment of quality of life using the SF-36 and GSRS questionnaires in patients with chronic pancreatitis (CP) in combination with comorbid pathology of the organs of the gastroduodenal zone (GDZ) remain insufficiently studied and substantiated. The objective: to analyze the clinical symptoms and assessment of quality of life using the SF-36 and GSRS questionnaires in the comorbidity of chronic pancreatitis with H. pylori-associated chronic gastritis. Materials and methods. An examination and study of indicators of 30 outpatients with CP and 117 patients with CP in comorbidity with chronic gastritis (CG) associated with H. pylori was carried out. 87 (59.2%) men and 60 (40.8%) women from 19 to 76 years old (average age - 48.29±1.04 years) were the participants. The control group included 30 practically healthy persons, comparable in age and sex. The clinical manifestations of the participants of the study groups were analyzed. For a reliable assessment of the quality of life, groups of patients were compared: the control group, patients with CP and patients with comorbidities. The physical and psychological components were evaluated using the SF-36 questionnaire. Indicators of the quality of life components of patients according to the scales of the GSRS questionnaire were also studied. Results. Clinical symptomatology in the comorbidity of CP with concomitant gastroduodenal disorders had features compared to those in isolated CP. Painful, dyspeptic, enteropancreatic and asthenovegetative, anemic syndromes were more often detected in patients with CP and disorders of the gastrointestinal tract. It was found that the average total score of the physical component in patients with CP and comorbidity was significantly lower than that in the group of isolated CP according to the SF-36 questionnaire: the difference between the values of the average total score of the physical component of quality of life in patients of the comparison groups was 10.42 points (11.2%). Conclusions. The results of the study show that the difference between the total indicators of the scales of the psychological component of the quality of life according to the SF-36 questionnaire of the groups of patients with CP and patients with comorbidity is 9.71 (11.5%). This proves that the psychological state of patients with CP with accompanying gastroduodenal changes is significantly worse. [ABSTRACT FROM AUTHOR]