THERAPEUTIC EFFECTS OF PLANT-DERIVED EXOSOMES ON DIFFERENT CANCER CELLS.

Plant-derived exosomes (PDEs) are natural extracellular vesicles. Research on them has called attention to advances in cancer treatment in recent years. Cancer is the global health crisis of our time and requires treatment that is effective, cost-effective, and has fewer side effects. New studies based on PDEs show that they have great potential to be considered as a therapeutic option. Research results show that the internal molecular charge of PDEs has less toxicity and they have effective anti-cancer activity. The main components of PDEs are lipids, proteins, DNA, and RNA. This review analyzed the available research on the factors that play a role in the effectiveness of the mechanism of action of plant-derived exosomes, based on their potential for medical purposes. As a result of the research, it was determined that the interaction with genes, the form of acquisition, which part of the plant to use, and whether or not an auxiliary agent is used, play an important role in the mechanism of action of such PDEs. It should be noted that the exosomes of each of the investigated plants did not have the same effect on all types of diseases, and their effectiveness varied depending on the diseases. [ABSTRACT FROM AUTHOR]