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Synthesis of 1,2′‐Spirobi[indene]‐1,3‐diones by Pd(II)‐Catalyzed C−H Activation and Alkynes Annulation Reaction.
- Source :
-
Advanced Synthesis & Catalysis . 7/2/2024, Vol. 366 Issue 13, p2926-2932. 7p. - Publication Year :
- 2024
-
Abstract
- An intermolecular annulation reaction of 2‐aryl‐1,3‐indandions with alkynes was reported using Pd(OAc)2 to access spirobi[indene]‐1,3‐diones. Under palladium catalysis, the substrates form a homocoupling dimer intermediate through a catalytic dehydrogenative cross‐coupling process. The palladium(II) species could come from dimer or 2‐aryl‐1,3‐indandion. Notably, this pathway is not typically observed in enol‐directed formal sp3 C−H functionalization/oxidative annulation palladium chemistry. This transformation provides a route to access a class of functionalized spiro carbocyclic indenes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANNULATION
*INDENE
*ALKYNES
*BIOCHEMICAL substrates
*PALLADIUM
*PALLADIUM catalysts
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 366
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 178532859
- Full Text :
- https://doi.org/10.1002/adsc.202400223