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Despite treatment, HbA1c ≥ 37 mmol/mol in the first trimester is associated with premature delivery among South Asian women with gestational diabetes mellitus: a retrospective cohort study.
- Source :
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Archives of Gynecology & Obstetrics . Aug2024, Vol. 310 Issue 2, p863-872. 10p. - Publication Year :
- 2024
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Abstract
- Purpose: To examine the effects of first-trimester HbA1c (HbA1c-FT) ≥ 37 mmol/mol on preterm birth (PTB) and large-for-gestational-age (LGA) babies in a retrospective cohort of South Asian pregnant women with gestational diabetes (GDM). Methods: The cohort (n = 686) was separated into two groups based on HbA1c-FT values: Group A (n = 97) and Group B (n = 589), with values of 37–46 mmol/mol (5.5–6.4%) and < 37 mmol/mol (5.5%), respectively. HbA1c-FT's independent influence on PTB and LGA babies was examined using multivariable logistic regression in groups A and B women. The reference group (Group C) included 2031 non-GDM women with HbA1c-FT < 37 mmol/mol (< 5.5%). The effects of HbA1c-FT on PTB and LGA babies in obese women in Groups A, B, and C (designated as A-ob, B-ob, and C-ob, respectively) were re-analyzed using multivariable logistic regression. Results: Group A GDM women with greater HbA1c-FT had a higher risk for PTB (aOR:1.86, 95% CI:1.10–3.14) but not LGA babies (aOR:1.13, 95%: 0.70–1.83). The risk of PTB was higher for obese women in Group A-ob: aOR 3.28 [95% CI 1.68–6.39]. However, GDM women with normal HbA1c-FT exhibited no elevated risk for PTB: Groups B and B-ob had aORs of 1.30 (95% CI 0.86–1.98) and 1.28 (95% CI 0.88–1.85) respectively. Conclusions: South Asian GDM women with prediabetic HbA1c FT; 37–46 mmol/mol (5.5–6.4%) are more likely to deliver preterm babies despite treatment, while the risk for LGA babies was the same as non-GDM women. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09320067
- Volume :
- 310
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Archives of Gynecology & Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 178528975
- Full Text :
- https://doi.org/10.1007/s00404-024-07422-4