ROR1 在不同组织学分级浸润性肺腺癌中的表达与临床意义.

Objective To investigate the expression of receptor tyrosine kinase-like orphan rectetpor 1 (ROR1) in invasive lung adenocarcinoma with different histological grades, and to analyze its relationship with histopathological grade of lung adenocarcinoma so as to explore whether it can be used as a potential indicator for the diagnostic evaluation of invasive lung adenocarcinoma. Methods A total of 290 paraffin-embedded tissue specimens of invasive lung adenocarcinoma were collected, and the relationship between ROR1 expression and invasive lung adenocarcinoma grade was statistically analyzed by HE staining sections. Results ROR1 was significantly highly expressed in the poorly differentiated invasive lung adenocarcinoma (P < 0.001), the Ki-67 index in the low-differentiated group was significantly higher than that in the high-differentiation and medium-differentiated groups (P < 0.001), and the Ki-67 index was higher in the high-expression group than in the low-expression group (P < 0.01). Conclusion There are significant differences in the expression levels of ROR1 in different grades of lung adenocarcinoma, and its expression level is closely related to the degree of differentiation and malignancy of invasive lung adenocarcinoma, which makes it possible to become a new biomarker for the diagnosis of lung adenocarcinoma and assist in the evaluation of clinical features and prognosis of lung adenocarcinoma, and provide a scientific basis to formulate personalized treatment strategies for patients. [ABSTRACT FROM AUTHOR]