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Parameter identifiability of a within-host SARS-CoV-2 epidemic model.

Authors :
Junyuan Yang
Sijin Wu
Xuezhi Li
Xiaoyan Wang
Xue-Song Zhang
Lu Hou
Source :
Infectious Disease Modelling (2468-2152). Sep2024, Vol. 9 Issue 3, p975-994. 20p.
Publication Year :
2024

Abstract

Parameter identification involves the estimation of undisclosed parameters within a system based on observed data and mathematical models. In this investigation, we employ DAISY to meticulously examine the structural identifiability of parameters of a within-host SARS-CoV-2 epidemic model, taking into account an array of observable datasets. Furthermore, Monte Carlo simulations are performed to offer a comprehensive practical analysis of model parameters. Lastly, sensitivity analysis is employed to ascertain that decreasing the replication rate of the SARS-CoV-2 virus and curbing the infectious period are the most efficacious measures in alleviating the dissemination of COVID-19 amongst hosts. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
24682152
Volume :
9
Issue :
3
Database :
Academic Search Index
Journal :
Infectious Disease Modelling (2468-2152)
Publication Type :
Academic Journal
Accession number :
178494992
Full Text :
https://doi.org/10.1016/j.idm.2024.05.004