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Antiplatelet and Antithrombotic Properties of Compound L-36, a 6H-1,3,4-Thiadiazine Derivative.
- Source :
-
Bulletin of Experimental Biology & Medicine . May2024, Vol. 177 Issue 1, p63-67. 5p. - Publication Year :
- 2024
-
Abstract
- Compound L-36, a new derivative of 6H-1,3,4-thiadiazine, was studied in in vitro and in vivo experiments. This compound exhibits high antiplatelet and antithrombogenic activity. In in vitro experiments, compound L-36 by its antiplatelet activity (by IC50) was superior to acetylsalicylic acid by 9.4 times. In in vivo experiments, compound L-36 by its ED50 value was close to the comparison drug. On the model of pulmonary artery thrombosis, compound L-36 ensured better survival of experimental animals than acetylsalicylic acid. Morphological studies showed that compound L-36 effectively attenuated the thrombosis processes in the pulmonary tissue induced by intravenous injection of a thrombogenic mixture (epinephrine and collagen). [ABSTRACT FROM AUTHOR]
- Subjects :
- *ASPIRIN
*INTRAVENOUS injections
*LABORATORY animals
*THROMBOSIS
*ADRENALINE
Subjects
Details
- Language :
- English
- ISSN :
- 00074888
- Volume :
- 177
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Bulletin of Experimental Biology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 178462067
- Full Text :
- https://doi.org/10.1007/s10517-024-06132-w