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Long-term humoral and cellular responses elicited by Gam-COVID-Vac vaccine in hemodialysis patients: A prospective cohort study.
- Source :
-
Electronic Journal of General Medicine . Aug2024, Vol. 21 Issue 4, p1-7. 7p. - Publication Year :
- 2024
-
Abstract
- Purpose: The aim of this study is to assess long-term immunogenicity of the recombinant adenoviruses 26 and 5 vector-based COVID-19 vaccine Gam-COVID-Vac (Sputnik V, developed by N. F. Gamaleya National Research Centre, Russia) in patients receiving maintenance hemodialysis (HD) compared to healthy subjects. Materials & methods: A prospective cohort study included patients treated with maintenance HD (n=23) and healthy volunteers (n=28). The levels of anti-severe acute respiratory syndrome coronavirus-2 specific IgG as well as specific T-cell responses were quantified in all participants at two time points: one and six months after complete vaccination. All participates were adults, had been vaccinated twice with Gam-COVID-Vac and had no prior history of confirmed COVID-19. Results: In both groups, IgG levels decreased from month one to six, however, antibodies did not decline more rapidly in HD group (analysis of variance p=0.7214 for the "time×group" interaction, non-adjusted model). At the end of the study, 48.0% of non-HD and 67.0% of HD participants showed T-cell positivity. T-spot counts dropped over time in non-HD controls, but not in HD subjects (p=0.0080 and p=0.1800, respectively). Conclusions: Patients receiving HD maintain significant long-term humoral response after Gam-COVID-Vac vaccination, which is comparable to that in subjects with normal kidney function. Cellular response turned up to be more sustained over time in HD group. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEPTIDE vaccines
*RESEARCH funding
*T cells
*DATA analysis
*T-test (Statistics)
*ADENOVIRUSES
*IMMUNOGLOBULINS
*SCIENTIFIC observation
*ENZYME-linked immunosorbent assay
*COVID-19 vaccines
*CELLULAR immunity
*HEMODIALYSIS
*HEMODIALYSIS facilities
*DESCRIPTIVE statistics
*ANTIBODY formation
*LONGITUDINAL method
*STATISTICS
*BIOAVAILABILITY
*SERODIAGNOSIS
*CONFIDENCE intervals
*COVID-19
Subjects
Details
- Language :
- English
- ISSN :
- 25163507
- Volume :
- 21
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Electronic Journal of General Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 178458989
- Full Text :
- https://doi.org/10.29333/ejgm/14786