A methodological pipeline for the preclinical evaluation of novel topical agents for the treatment of CRS.

Authors :: Hale, Samuel J. M.
Lux, Christian A.
Willoughby, James E.
Koefoed, Arne
Broderick, David
Biswas, Kristi
Kim, Raymond
Mackenzie, Brett Wagner
Douglas, Richard G.
Source :: International Forum of Allergy & Rhinology. Jul2024, p1. 4p. 1 Illustration.
Publication Year :: 2024
Abstract: Key points Novel topical therapeutics require extensive pre‐clinical testing to assess efficacy and safety. Antibiofilm or immunosuppressant agents can utilize ex vivo models to measure ciliotoxicity. Agents that are found to be effective and non‐toxic ex vivo warrant further investigation in vivo. [ABSTRACT FROM AUTHOR]

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