A CD10‐negative adult B‐lymphoblastic leukaemia with amplification of KMT2A without rearrangement: A case report and review of the English literature.

This article discusses a rare case of CD10-negative adult B-lymphoblastic leukemia (B-LBL) with amplification of the KMT2A gene without rearrangement. The KMT2A gene is typically associated with myeloid neoplasms but rarely occurs in B-LBL. The patient in this case was a 70-year-old female who presented with pancytopenia and was found to have a high percentage of lymphoblasts in her bone marrow. The article provides detailed information about the patient's diagnosis, including flow cytometry, karyotyping, fluorescence in situ hybridization (FISH), and genetic analysis. The article also discusses the similarities and differences between B-LBL with KMT2A amplification and B-LBL with KMT2A rearrangements. The prognosis for patients with KMT2A amplification is generally poor, and this case was no exception, as the patient passed away shortly after diagnosis. Overall, this article provides valuable information about a rare and poorly understood form of B-LBL. [Extracted from the article]