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Clinical utility of investigations in triple‐negative thrombocytosis: A real‐world, multicentre evaluation of UK practice.
- Source :
-
British Journal of Haematology . Jul2024, p1. 6p. 2 Illustrations. - Publication Year :
- 2024
-
Abstract
- Summary Diagnosis of essential thrombocythaemia (ET) is challenging in patients lacking JAK2/CALR/MPL mutations. In a retrospective evaluation of 320 patients with ‘triple‐negative thrombocytosis’, we assessed utility of bone marrow histology (90.9% of patients) and myeloid gene panel (MGP, 55.6%). Supportive histology (‘myeloproliferative neoplasm‐definite/probable’, 36.8%) was associated with higher platelet counts and varied between centres. 14.6% MGP revealed significant variants: 3.4% JAK2/CALR/MPL and 11.2% other myeloid genes. Final clinical diagnosis was strongly predicted by histology, not MGP. 23.7% received cytoreduction (17.6% under 60 years). Real‐world ‘triple‐negative’ ET diagnosis currently depends heavily on histology; we advocate caution in MGP‐negative cases and that specific guidelines are needed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THROMBOCYTOSIS
*PLATELET count
*BONE marrow
*HISTOLOGY
*MYELOFIBROSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Database :
- Academic Search Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 178379874
- Full Text :
- https://doi.org/10.1111/bjh.19643