A systematic review of Indonesian traditional Jamu medicine.

Purpose: To systematically review the Indonesian Jamu reference book and summarize the available literature on commonly used formula for conditions like hypercholesterolemia, hypertension, skin diseases, arthritis, sexual disorders, and liver health. Gaps are highlighted and recommendations are made for future studies. Methods: Relevant information was extracted from book chapters into predefined categories. PubMed and Scopus were searched systematically for clinical trials, animal studies, and in vitro experiments evaluating Jamu formula and ingredients described in the book. Thirty (30) eligible studies were analyzed regarding proposed mechanisms of action, safety and efficacy. Results: Significant anti-hyperlipidemic, antihypertensive, hepatoprotective and other relevant bioactivities were demonstrated in animal models evaluating formulations containing Curcuma xanthorrhiza, Curcuma longa, Orthosiphon stamineus, celery, green tea and Caesalpinia sappan. Small pilot trials also showed beneficial effect, but clinical studies are limited regarding quality and sample sizes. Conclusion: The findings provide preliminary pharmacological evidence largely supporting traditional Jamu use. However, well-designed randomized controlled trials in larger patient samples are needed to conclusively demonstrate therapeutic efficacy and clinical safety. [ABSTRACT FROM AUTHOR]