先天性巨结肠手术后小肠结肠炎的 危险因素分析.

Objective To explore the risk factors of postoperative Hirschsprung-associated enterocolitis (HAEC) within 1 year. Methods From January 2011 to June 2021, the relevant clinical data were retrospectively reviewed for 313 children with Hirschsprung's disease (HSCR). They were assigned into two groups of postoperative HAEC (n=47) and no postoperative HAEC (n = 266). The risk factors of postoperative HAEC included patient gender, age of radical operation, microcytic hypochromic anemia, preoperative HAEC history, preoperative colostomy, pathological classification and hypoalbuminemia. Results Patient gender or age of radical operation showed no difference of statistical significance (P>0.05). And microcytic hypochromic anemia [(59.6%,28/47) υς. (35.3%, 94/266)], preoperative HAEC [(44.7%,21/47) vs. (22.6%,60/266)], preoperative colostomy [(23.4%,11/47) vs. (10.2%,27/266)], long segment or total colonic HSCR [(34.0%, 16/47) vs. (16.9%,45/266)] and hypoalbuminemia [(80.9%,38/47) vs. (66.2%, 176/266)] revealed statistically significant differences (P<0.05). Multiple Logistic regression analysis indicated that microcytic hypochromic anemia (OR=2.522,95% CI:1.301-4.887) and preoperative HAEC(OR=2.812,95% CI:1.415-5.589) were correlated with postoperative HAEC. Conclusions Complication of microcytic hypochromic anemia and preoperative HAEC are the risk factors of postoperative HAEC. Focusing upon the risk factors of postoperative HAEC can effectively lower the most serious complications of HSCR after radical operation and improve the quality-of-life of children. [ABSTRACT FROM AUTHOR]