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Cerebellar gray matter and white matter damage among older adults with prediabetes.
- Source :
-
Diabetes Research & Clinical Practice . Jul2024, Vol. 213, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- • Damage to the white matter and gray matter of the cerebellum has already occurred in prediabetes. • Damage of the cerebellum is more serious in the stage of diabetes. • The damaged brain area with prediabetic lesions was closely related to motor function. • The area affected by diabetes was related to complex cognitive function. To investigate alterations in cerebrum and cerebellum in prediabetes. Cerebellar injury in diabetes is traceable, but it has not been systematically studied, and whether cerebellar injury occurs and the degree of damage in prediabetes are not known. The current study investigated cerebral and cerebellar gray matter volume, white matter volume, white matter microstructure and white matter hyperintensity on T1-weighted, T2-weighted fluid-attenuated inversion recovery and diffusion tensor imaging scans in 78 individuals with normal glucose metabolism, 92 with prediabetes, and 108 with type 2 diabetes. Participants with prediabetes showed significant gray matter and white matter atrophy, microstructural damage in the cerebellar and cerebral regions. Additionally, widespread structural alterations were observed in the diabetic stage. The function of the damaged brain area was further decoded in Neurosynth, and the damaged cerebellar area with prediabetic lesions was closely related to motor function, while the area affected by diabetes was related to complex cognitive function in addition to motor function. Cerebellar injury had already appeared in the prediabetic stage, and cerebellar injury was aggravated in the diabetic stage; therefore, the cerebellum is a key area that is damaged early in the development of diabetes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 213
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 178357605
- Full Text :
- https://doi.org/10.1016/j.diabres.2024.111731