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MRSA infection, re‐infection and clinical outcomes in diabetic foot infections.
- Source :
-
Wound Repair & Regeneration . Jul2024, Vol. 32 Issue 4, p377-383. 7p. - Publication Year :
- 2024
-
Abstract
- The aim was to investigate methicillin‐resistant Staphylococcus aureus (MRSA) incidence, conversion and outcomes in diabetic foot infections (DFIs). This is a pooled patient‐level analysis of combined data sets from two randomised clinical trials including 219 patients admitted to the hospital with moderate or severe DFIs. Intraoperative bone and tissue cultures identified bacterial pathogens. We identified pathogens at index infections and subsequent re‐infections. We identified MRSA conversion (MSSA to MRSA) in re‐infections. MRSA incidence in index infections was 10.5%, with no difference between soft tissue infections (STIs) and osteomyelitis (OM). MRSA conversion occurred in 7.7% of the re‐infections in patients who initially had MSSA in their cultures. Patients with re‐infection were 2.2 times more likely to have MRSA compared to the first infection (10.5% vs. 25.8%, relative risk [RR] = 2.2, p = 0.001). Patients with MRSA had longer antibiotic treatment during the 1‐year follow‐up, compared to other pathogens (other 49.8 ± 34.7 days, MRSA 65.3 ± 41.5 days, p = 0.04). Furthermore, there were no differences in healing, time to heal, length of stay, re‐infection, amputation, re‐ulceration, re‐admission, surgery after discharge and amputation after discharge compared to other pathogens. The incidence of MRSA at the index was 10.5% with no difference in STI and OM. MRSA incidence was 25.8% in re‐infections. The RR of having MRSA was 2.2 times higher in re‐infections. Patients with MRSA used more antibiotics during the 1‐year follow‐up. Furthermore, there were no differences in clinical outcomes compared to other bacterial pathogens. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RISK assessment
*SOFT tissue infections
*AMPUTATION
*WOUND healing
*STAPHYLOCOCCAL diseases
*RESEARCH funding
*DATA analysis
*GLYCOSYLATED hemoglobin
*OSTEOMYELITIS
*PATIENT readmissions
*HOSPITAL care
*METHICILLIN-resistant staphylococcus aureus
*SEVERITY of illness index
*DESCRIPTIVE statistics
*RELATIVE medical risk
*SURGICAL therapeutics
*MANN Whitney U Test
*CHI-squared test
*BLOOD sedimentation
*REINFECTION
*KAPLAN-Meier estimator
*LOG-rank test
*DIABETIC foot
*STATISTICS
*MEDICAL records
*ACQUISITION of data
*SURVIVAL analysis (Biometry)
*DISEASE incidence
*C-reactive protein
*DISEASE risk factors
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 10671927
- Volume :
- 32
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Wound Repair & Regeneration
- Publication Type :
- Academic Journal
- Accession number :
- 178355113
- Full Text :
- https://doi.org/10.1111/wrr.13164