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Long-term exposure to PM2.5 compositions and O3 and their interactive effects on DNA methylation of peripheral brain-derived neurotrophic factor promoter.
- Source :
-
International Journal of Environmental Health Research . Aug2024, Vol. 34 Issue 8, p2957-2968. 12p. - Publication Year :
- 2024
-
Abstract
- This study examined the associations of long-term exposure to ambient fine particulate matter (PM2.5) compositions/ozone with methylation of peripheral brain-derived neurotrophic factor (BDNF) promoters. A total of 101 participants were recruited from a cohort in Shijiazhuang, Hebei province, China. They underwent baseline and follow-up surveys in 2011 and 2015. DNA methylation levels were detected by bisulfite-PCR amplification and pyrosequencing. Participants' three-year average levels of PM2.5 compositions and ozone were estimated. Bayesian kernel machine regression (BKMR) models were used to examine the joint effects of pollutants on methylation levels. Exposure to PM2.5 compositions and ozone mixtures at the 75th percentile was associated with increased methylation levels at CpG2 of BDNF promoter (203%, 95% CI: 89, 316) than the lowest level of exposure, and sulfate dominated the effect in the BKMR models.Our findings provide clues to the epigenetic mechanisms for the associations of PM2.5 compositions and ozone with BDNF. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RESEARCH funding
*POLYMERASE chain reaction
*STATISTICAL sampling
*SULFATES
*DESCRIPTIVE statistics
*DNA methylation
*LONGITUDINAL method
*SURVEYS
*OZONE
*BRAIN-derived neurotrophic factor
*ENVIRONMENTAL exposure
*PARTICULATE matter
*CONFIDENCE intervals
*SEQUENCE analysis
*REGRESSION analysis
Subjects
Details
- Language :
- English
- ISSN :
- 09603123
- Volume :
- 34
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- International Journal of Environmental Health Research
- Publication Type :
- Academic Journal
- Accession number :
- 178337031
- Full Text :
- https://doi.org/10.1080/09603123.2023.2280157