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The synthesis and antitumor activity of novel 1-alkyl-3-phenyland 3-alkyl-1-phenylimidazothiazolotriazines.
- Source :
-
Chemistry of Heterocyclic Compounds . Apr2024, Vol. 60 Issue 3/4, p196-204. 9p. - Publication Year :
- 2024
-
Abstract
- Two groups of isomeric imidazothiazolo[1,2,4]triazines and their oxindolylidene derivatives were obtained from 1-alkyl-3-aryl-4,5-dihydroxyimidazolidin-2-(thi)ones. One of the synthesized imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazine derivatives showed high cytostatic activity at a concentration of 10 μmol/l against four lines of tumor cells: HL-60(TB) (leukemia, –16.1% growth rate), SF-539 (CNS cancer, –2.6% growth rate), MDA-MB-435 (melanoma, –21.2% growth rate), and RXF 393 (kidney cancer, –6.1 % growth rate). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00093122
- Volume :
- 60
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Chemistry of Heterocyclic Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 178333634
- Full Text :
- https://doi.org/10.1007/s10593-024-03318-y