GREEN METHOD FOR THE SPECTROPHOTOMETRIC DETERMINATION OF PHENYLEPHRINE AND TERBUTALINE PHARMACEUTICAL FORMULATIONS.

Determination and evaluation active substances in chemical settings is extremely difficult, linked to chemical waste in water sewage, and may eventually have an influence on public health. As a result, efforts are being made globally to find other, perhaps less hazardous ways. Hereby, we aimed to determine two pharmaceutical products for the detection of phenylephrine hydrochloride and terbutaline sulphate using green chemistry. The procedure involves oxidizing phenylephrine hydrochloride and terbutaline sulphate using potassium permanganate as an oxidant and decolorizing the surplus of potassium permanganate in the reaction with Nile blue dye. The results confirmed that this method has provided easy and precise evaluation of phenylephrine hydrochloride and terbutaline sulphate at concentrations ranging from (0.4-4.5) µg /ml, with molar absorption capacity of (6.9x104 ) l‧mol-1 ‧cm -1 for phenylephrine hydrochloride and (1.44×105 ) l‧mol-1 ‧cm-1 for terbutaline sulphate. The methodologies have precisely determined the pharmaceutical dosage forms of the tested drugs, agreeing with previously tested and stated values and standard compounds. [ABSTRACT FROM AUTHOR]