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Granulomatous dermatitis in the context of chronic myelomonocytic leukemia: More than just reactive infiltrates. An illustrative case report with literature review.

Authors :
García‐García, Mar
Elbaile, Julia Jiménez
Azaceta, Gemma
Lorda, Marta
Prieto‐Torres, Lucía
Source :
Journal of Cutaneous Pathology. Aug2024, Vol. 51 Issue 8, p598-603. 6p.
Publication Year :
2024

Abstract

Traditionally, skin involvement in chronic myelomonocytic leukemia (CMML) has been considered to be either specific (leukemia cutis) or non‐specific, with granulomatous dermatitis included in the latter group. More recently, the true nature of the myeloid cells present in the cutaneous infiltrates of this theoretically reactive dermatitis is being clarified with the use of new molecular techniques such as next‐generation sequencing. The same mutations in bone marrow (BM) myeloid neoplastic cells and in the cells of cutaneous infiltrates have been found. We present the case of a 77‐year‐old man who presented with spread and treatment‐resistant skin granulomatous lesions previous to the diagnosis of CMML. The same clonal mutations in SRSF2, IDH1, and RUNX1 were found in both skin and BM with resolution of the lesions after the initiation of azacytidine. In conclusion, we report an exceptional case in which specific granulomatous cutaneous lesions have preceded and allowed the earlier diagnosis of an underlying CMML and a review of all previous similar cases in the literature, including molecular alterations. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03036987
Volume :
51
Issue :
8
Database :
Academic Search Index
Journal :
Journal of Cutaneous Pathology
Publication Type :
Academic Journal
Accession number :
178316908
Full Text :
https://doi.org/10.1111/cup.14638