右美托咪定在老年肺癌合并 COPD 患者中的麻醉效果及对应激反应 和 Th1、Th2 型细胞因子的影响.

To observe the anesthetic effect of dexmedetomidine in elderly patients with lung cancer combined with chronic obstructive pulmonary disease (COPD) and its effect on stress response and auxiliary T (Th) 1 and Th2 cytokines. 100 elderly patients with lung cancer combine with COPD who underwent lobectomy in our hospital from May 2019 to May 2022 were divided into control group and treatment group by random number table method, with 50 cases in each group. Control group received routine anesthesia, and treatment group received dexmedetomidine on the basis in control group. The pulmonary dynamic compliance, oxygenation index, stress response index, Th1 and Th2 cytokines were compared in two groups, and the incidence of complications in two groups was recorded after operation. The pulmonary dynamic compliance and oxygenation index in treatment group were higher than those in control group at 30 min (T2) to the end of operation (T4) (P<0.05). The levels of cortisol (Cor), adrenocorticotropic hormone (ACTH), norepinephrine (NE) and epinephrine (E) in treatment group were lower than those in control group 1 day after operation (P<0.05). The levels of interleukin-2 (IL-2), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) in treatment group were lower than those in control group 1 day after operation (P<0.05), and the levels of IL-4 and IL-10 were higher than those in control group (P<0.05). There was no difference in the incidence of complications in two groups after operation (P>0.05) Dexmedetomidine has a good anesthetic effect on elderly patients with lung cancer combined with COPD, which can improve lung compliance, maintain stable oxygenation index, reduce the body's stress response, and effectively regulate Th1 and Th2 cytokines. [ABSTRACT FROM AUTHOR]