早发型重度子痫前期患者血清 ADMA、INH-A 与胎儿生长受限的 关系研究.

Objective: To investigate the relationship between serum asymmetric dimethylarginine (ADMA）, inhibin A (INH-A）and fetal growth restriction (FGR) in patients with early onset severe preeclampsia (SPE）. Methods: 110 patients with early onset SPE who were delivered in The First Affiliated Hospital of Hainan Medical University from January 2021 to January 2023 were selected as observation group, and 100 healthy pregnant women were selected as control group, patients with early onset SPE were divided into FGR group (46 cases) and no FGR group (64 cases) according to whether FGR was combined. The levels of serum ADMA and INH-A in observation group and control group were compared. The influencing factors of FGR in patients with early onset SPE were analyzed by multivariate Logistic regression analysis, the predictive effect of serum ADMA and INH-A levels on FGR in patients with early onset SPE were analyzed by receiver operating characteristic curve (ROC）. Results: Compared with control group, the levels of serum ADMA and INH-A in observation group were increased (P＜0.05）. Compared with no FGR group, the levels of ADMA, INH-A, systolic blood pressure, diastolic blood pressure, serum creatinine, 24 h urinary protein quantification, and umbilical artery blood flow end-systolic velocity/end-diastolic velocity ratio (S/D) were increased in FGR group, while the pre-pregnancy body mass index (BMI) was decreased (P＜0.05）. Multivariate Logistic regression analysis showed that, 24 h urinary protein quantification, arterial blood flow S/D, ADMA and INH-A were independent risk factors for FGR in patients with early onset SPE (P＜0.05）. ROC analysis showed that, the area under the curve of combined prediction of serum ADMA and INH-A levels in patients with early onset SPE complicated with FGR was greater than that of single prediction. Conclusion: The levels of serum ADMA and INH-A in patients with early onset SPE are abnormally increase, and are involve in the occurrence and development of FGR, in addition, the combination of serum ADMA and INH-A levels has a high predictive efficiency for FGR in patients with early onset SPE. [ABSTRACT FROM AUTHOR]