Quercetin-incorporated collagen/chitosan/SiO2 composite toward the robust antioxidant biomaterials.

This investigation aims at providing a novel approach to producing high-performance antioxidant material. Indeed, quercetin molecules incorporated into collagen/chitosan/SiO2 composite through direct interactions have been reported for the first time. Such internal linking has been found as the primary reason for improving the stability of the entire system and enhancing the permanent existence of strongly active biomaterials. Consequently, in vitro antioxidant tests revealed that the obtained materials (denoted as CS/Col/SiO2/Q) provide outstanding antioxidant activity. Thus the CS/Col/SiO2/Q sample exhibits cytotoxicity to HepG2, MKN7, and MCF-7 cancer cells. These results demonstrate that the obtained composite turns out to be very promising as a bioactive material for biomedical applications. [ABSTRACT FROM AUTHOR]