Reduction hits the sweet spot: A revised biosynthesis of dolichol.

Dolichol is a lipid that is involved in protein glycosylation, a process that is essential for all eukaryotic life. In this issue of Cell , Wilson and coworkers 1 report how a rare human genetic disorder led to the discovery of dolichol biosynthesis. Dolichol is a lipid that is involved in protein glycosylation, a process that is essential for all eukaryotic life. In this issue of Cell , Wilson and coworkers report how a rare human genetic disorder led to the discovery of dolichol biosynthesis. [ABSTRACT FROM AUTHOR]