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Congenital Adrenal Hyperplasia in Children: The Relationship between Plasma Renin Activity and Hypertension.
- Source :
-
Iranian Journal of Medical Sciences . Jun2024, Vol. 49 Issue 6, p377-383. 7p. - Publication Year :
- 2024
-
Abstract
- Background: Children with Congenital Adrenal Hyperplasia (CAH) have a higher chance of hypertension. The likelihood of hypertension is higher in CAH children who get fludrocortisone medication and have an over-suppression. Plasma renin activity (PRA) is a sensitive indicator when the fludrocortisone dose is insufficient. The objective of this study is to assess the relationship between plasma renin activity with hypertension in 21-hydroxylase-deficient (21-OHD) CAH children. Methods: This cross-sectional observational analytical study was conducted in 2019 at the Pediatric Endocrinology Outpatient Clinic in Dr. Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia. The subjects were 21-OHD CAH children, aged >6 months to 18 years who had already taken hydrocortisone with or without fludrocortisone for at least 6 months, and were divided into hypertension and non-hypertension groups. The subjects were selected by a consecutive sampling method. Data was analyzed using SPSS software (version 23.0) with unpaired t test analysis and multiple logistic regression test. Statistical significance was achieved if P<0.05. Results: Forty 21-OHD CAH patients were included, and 20 subjects (50%) had hypertension. A higher incidence of hypertension was found in salt-wasting CAH than in simple virilizing types (59.3% vs 30.8%). There was a significant mean difference in PRA levels between hypertension and non-hypertension groups in salt-wasting patients (P=0.016). A significant difference between the last dose of hydrocortisone with the number of hypertension patients in saltwasting patients (P=0.032) was found, and low PRA levels showed a 1.09 times higher risk of hypertension. Conclusion: Children with salt-wasting CAH with low PRA levels had a higher risk of getting hypertension. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYPERTENSION risk factors
*SODIUM metabolism
*ADRENOGENITAL syndrome
*RENIN
*RISK assessment
*CROSS-sectional method
*T-test (Statistics)
*BODY mass index
*ADRENAL insufficiency
*SCIENTIFIC observation
*LOGISTIC regression analysis
*HYDROCORTISONE
*ADRENAL diseases
*DESCRIPTIVE statistics
*DATA analysis software
*DISEASE complications
*CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 02530716
- Volume :
- 49
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Iranian Journal of Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 178278118
- Full Text :
- https://doi.org/10.30476/ijms.2023.98508.3058