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Upper gastrointestinal bleeding on veno-arterial extracorporeal membrane oxygenation support.
- Source :
-
Annals of Intensive Care . 7/3/2024, Vol. 14 Issue 1, p1-9. 9p. - Publication Year :
- 2024
-
Abstract
- Introduction: Patients on veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support are at a high risk of hemorrhagic complications, including upper gastrointestinal bleeding (UGIB). The objective of this study was to evaluate the incidence and impact of this complication in V-A ECMO patients. Materials and methods: A retrospective single-center study (2013–2017) was conducted on V-A ECMO patients, excluding those who died within 24 h. All patients with suspected UGIB underwent esophagogastroduodenoscopy (EGD) and were analyzed and compared to the remainder of the cohort, from the initiation of ECMO until 5 days after explantation. Results: A total of 150 V-A ECMO cases (65 after cardiac surgery and 85 due to medical etiology) were included. 90% of the patients received prophylactic proton pump inhibitor therapy and enteral nutrition. Thirty-one patients underwent EGD for suspected UGIB, with 16 confirmed cases of UGIB. The incidence was 10.7%, with a median occurrence at 10 [7–17] days. There were no significant differences in clinical or biological characteristics on the day of EGD. However, patients with UGIB had significant increases in packed red blood cells and fresh frozen plasma needs, mechanical ventilation duration and V-A ECMO duration, as well as in length of intensive care unit and hospital stays. There was no significant difference in mortality. The only independent risk factor of UGIB was a history of peptic ulcer (OR = 7.32; 95% CI [1.07–50.01], p = 0.042). Conclusion: UGIB occurred in at least 1 out of 10 cases of V-A ECMO patients, with significant consequences on healthcare resources. Enteral nutrition and proton pump inhibitor prophylaxis did not appear to protect V-A ECMO patients. Further studies should assess their real benefits in these patients with high risk of hemorrhage. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RISK assessment
*GASTROINTESTINAL hemorrhage
*EXTRACORPOREAL membrane oxygenation
*PEPTIC ulcer
*RETROSPECTIVE studies
*DESCRIPTIVE statistics
*CHI-squared test
*MANN Whitney U Test
*MULTIVARIATE analysis
*ODDS ratio
*MEDICAL records
*ACQUISITION of data
*COMPARATIVE studies
*CONFIDENCE intervals
*LENGTH of stay in hospitals
*DATA analysis software
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 21105820
- Volume :
- 14
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Annals of Intensive Care
- Publication Type :
- Academic Journal
- Accession number :
- 178276137
- Full Text :
- https://doi.org/10.1186/s13613-024-01326-x