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H3K9 methylation regulates heterochromatin silencing through incoherent feedforward loops.

Authors :
Kannosuke Yabe
Asuka Kamio
Satoyo Oya
Tetsuji Kakutani
Mami Hirayama
Yuriko Tanaka
Soichi Inagaki
Source :
Science Advances. 6/28/2024, Vol. 10 Issue 26, p1-10. 10p.
Publication Year :
2024

Abstract

Histone H3 lysine-9 methylation (H3K9me) is a hallmark of the condensed and transcriptionally silent heterochromatin. It remains unclear how H3K9me controls transcription silencing and how cells delimit H3K9me domains to avoid silencing essential genes. Here, using Arabidopsis genetic systems that induce H3K9me2 in genes and transposons de novo, we show that H3K9me2 accumulation paradoxically also causes the deposition of the euchromatic mark H3K- 36me3 by a SET domain methyltransferase, ASHH3. ASHH3-induced H3K36me3 confers anti-silencing by preventing the demethylation of H3K4me1 by LDL2, which mediates transcriptional silencing downstream of H3K9me2. These results demonstrate that H3K9me2 not only facilitates but orchestrates silencing by actuating antagonistic silencing and anti-silencing pathways, providing insights into the molecular basis underlying proper partitioning of chromatin domains and the creation of metastable epigenetic variation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23752548
Volume :
10
Issue :
26
Database :
Academic Search Index
Journal :
Science Advances
Publication Type :
Academic Journal
Accession number :
178263976
Full Text :
https://doi.org/10.1126/sciadv.adn4149