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Polygonatum sibiricum component liquiritigenin restrains breast cancer cell invasion and migration by inhibiting HSP90 and chaperone-mediated autophagy.

Authors :
Suli Xu
Zhao Ma
Lihua Xing
Weiqing Cheng
Source :
Korean Journal of Physiology & Pharmacology. Jul2024, Vol. 28 Issue 4, p379-387. 9p.
Publication Year :
2024

Abstract

Breast cancer (BC) is most commonly diagnosed worldwide. Liquiritigenin is a flavonoid found in various species of the Glycyrrhiza genus, showing anti-tumor activity. This article was to explore the influences of liquiritigenin on the biological behaviors of BC cells and its underlying mechanism. BC cells were treated with liquiritigenin alone or transfected with oe-HSP90 before liquiritigenin treatment. RTqPCR and Western blotting were employed to examine the levels of HSP90, Snail, Ecadherin, HSC70, and LAMP-2A. Cell viability, proliferation, migration, and invasion were evaluated by performing MTT, colony formation, scratch, and Transwell assays, respectively. Liquiritigenin treatment reduced HSP90 and Snail levels and enhanced E-cadherin expression as well as inhibiting the proliferation, migration, and invasion of BC cells. Moreover, liquiritigenin treatment decreased the expression of HSC70 and LAMP-2A, proteins related to chaperone-mediated autophagy (CMA). HSP90 overexpression promoted the CMA, invasion, and migration of BC cells under liquiritigenin treatment. Liquiritigenin inhibits HSP90-mediated CMA, thereby suppressing BC cell growth. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
12264512
Volume :
28
Issue :
4
Database :
Academic Search Index
Journal :
Korean Journal of Physiology & Pharmacology
Publication Type :
Academic Journal
Accession number :
178263680
Full Text :
https://doi.org/10.4196/kjpp.2024.28.4.379