TOTAL ANTIOXIDANT CAPACITY, TOTAL OXIDANT STATUS, D-DIMER AND NITRIC OXIDE LEVELS IN DOGS WITH PARVOVIRAL ENTERITIS.

Canine parvoviral enteritis remains one of the commonest causes of death in young dogs. This study aimed to determine serum total antioxidant capacity (TAC) and total oxidant status (TOS) levels in dogs with canine parvoviral enteritis (CPV) and reveal the risk factors of DIC formation. Thirty dogs were included in the study. The dogs were divided into two groups; the first group consisted of 20 dogs diagnosed with CPV (study group) and the other group consisted of 10 healthy dogs aged 0-12 months (control group). The mean TAC value was 0.354±0.018 mmol Trolox equiv./L in the control group and 0.295±0.007 mmol Trolox equiv./L in the study group. The mean TOS level was determined as 6.539±0.154 µmol H2O2/L in the control group and 7.934±0.364 µmol H2O2/L in the study group. The mean nitric oxide (NO) concentration was 18.613±0.856 µmol/L in the control group and 21.781±0.913 µmol/L in the study group. D-dimer levels were found to be 0.170±0.070 mg/dL in the control group and 2.585±0.584 mg/dL in the study group. As a result, it was demonstrated that it is essential to consider that oxidative stress increases and antioxidant capacity decreases in dogs with CPV and that disseminated intravascular coagulation (DIC) may develop in dogs with CPV. It is thought that considering oxidative stress and DIC during the treatment may contribute positively to prognosis and survival. [ABSTRACT FROM AUTHOR]