A Concise Route to Keto‐Bridged Polyphenols by Photo‐Fries Rearrangement in Flow.

Authors :: Lin, Xin‐Jie
Wang, Chien‐Lung
Peng, Chi‐How
Liu, Hsueh‐Ju
Wu, Yen‐Ku
Source :: Chemistry - An Asian Journal. 7/2/2024, Vol. 19 Issue 13, p1-4. 4p.
Publication Year :: 2024
Abstract: Described is a new synthetic route to bis(2‐hydroxy‐3,5‐di‐t‐butylphenyl)methanone and its derivatives. The combined esterification/photo‐Fries rearrangement approach enables a modular preparation of keto‐bridged polyphenols. This protecting group‐free process is highly atom‐ and step‐economic, and a scalable production was easily achieved in the continuous‐flow mode. [ABSTRACT FROM AUTHOR]

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