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Light-induced β-hydroxy sulfone synthesis in DNA-encoded libraries.
- Source :
-
Chemical Communications . 7/11/2024, Vol. 60 Issue 54, p6885-6888. 4p. - Publication Year :
- 2024
-
Abstract
- We here describe a visible-light photooxidation of sulfinate salts with common alkenes to yield β-hydroxy sulfones on DNA. This process demonstrates a broad substrate compatibility and achieves conversion rates ranging from moderate to excellent. Most importantly, it presents a straightforward, efficient, and metal-free approach for synthesizing Csp3-rich DNA-encoded libraries. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIBRARIES
*PHOTOOXIDATION
*ALKENES
*DNA
*SULFONES
*SALTS
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 60
- Issue :
- 54
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 178207046
- Full Text :
- https://doi.org/10.1039/d4cc02193b