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Coexistence of anti-glomerular basement membrane disease and IgA nephropathy: an illustrative case and comprehensive literature review.
- Source :
-
Renal Failure . Dec2024, Vol. 46 Issue 2, p1-9. 9p. - Publication Year :
- 2024
-
Abstract
- Anti-glomerular basement membrane (GBM) disease is a rare autoimmune condition characterized by the presence of positive anti-GBM autoantibodies, linear deposition of immunoglobulin G (IgG) along the GBM and severe kidney injury. In a limited number of cases, the association of anti-GBM disease with other glomerulonephritis has been reported. Herein, we present the case of a 66-year-old female patient with progressive worsen kidney function and decreased urine output. A renal biopsy revealed crescent glomerulonephritis with lineal IgG deposition along the GBM and mesangial IgA deposition, which supported the diagnosis of concurrent anti-GBM disease and IgA nephropathy (IgAN). In an extensive literature review, we identified a total of thirty-nine patients were reported anti-GBM disease combined with IgAN. The clinical characteristics of these patients demonstrate that the anti-GBM disease combined with IgAN tends to be milder with a more indolent course and a better prognosis than the classic anti-GBM disease, and its potential pathogenesis deserves to be further explored. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0886022X
- Volume :
- 46
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Renal Failure
- Publication Type :
- Academic Journal
- Accession number :
- 178179424
- Full Text :
- https://doi.org/10.1080/0886022X.2024.2323160