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Evaluation of critical parameters in the hollow‐fibre system for tuberculosis: A case study of moxifloxacin.

Authors :
Aguilar‐Ayala, Diana A.
Sanz‐García, Fernando
Rabodoarivelo, Marie Sylvianne
Susanto, Budi O.
Bailo, Rebeca
Eveque‐Mourroux, Maxime R.
Willand, Nicolas
Simonsson, Ulrika S. H.
Ramón‐García, Santiago
Lucía, Ainhoa
Source :
British Journal of Clinical Pharmacology. Jul2024, Vol. 90 Issue 7, p1711-1727. 17p.
Publication Year :
2024

Abstract

This article discusses the use of the hollow-fibre system for tuberculosis (HFS-TB) in drug development. The study aims to optimize and standardize operational procedures of the HFS-TB. The researchers conducted experiments to analyze the impact of various variables, such as bacterial adaptation time, cartridge size, and bacterial strain, on the effectiveness of moxifloxacin, a drug used to treat tuberculosis. The findings highlight the need for standardization and proper reporting of critical parameters in HFS-TB studies to improve the reliability and clinical relevance of the results. [Extracted from the article]

Details

Language :
English
ISSN :
03065251
Volume :
90
Issue :
7
Database :
Academic Search Index
Journal :
British Journal of Clinical Pharmacology
Publication Type :
Academic Journal
Accession number :
178131897
Full Text :
https://doi.org/10.1111/bcp.16068