Antibody inhibition of measles virus entry.

The article focuses on the process of virus-cell membrane fusion, particularly in paramyxoviruses like measles virus (MeV), where two viral glycoproteins collaborate to enter host cells and induce syncytia formation. Zyla et al. used advanced cryo-electron microscopy to reveal a novel intermediate step in MeV fusion triggered by the antibody mAb 77, highlighting its potential as a therapeutic by inhibiting viral entry at a crucial stage.