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Liver disease as a major cause of death among HIV infected patients: role of hepatitis C and B viruses and alcohol
- Source :
-
Journal of Hepatology . Jun2005, Vol. 42 Issue 6, p799-805. 7p. - Publication Year :
- 2005
-
Abstract
- Background/Aims: We analyzed the characteristics of HIV infected patients who died from liver disease, focusing on hepatitis virus co-infection. Methods: One-hundred and eighty-five French hospital departments involved in HIV/AIDS management prospectively notified all deaths occurring in 2000. Patients whose hepatitis C (HCV) and hepatitis B (HBV) serostatus was known were classified as being infected by HCV alone, HBV alone (HBsAg positive), both HCV and HBV, or neither HCV nor HBV. Results: Among 822 HIV infected patients, 29% were infected by HCV alone, 8% by HBV alone, and 4% by both HCV and HBV. The most frequent causes of death were liver disease (31% of cases) and AIDS (29%) among HIV–HCV co-infected patients, and AIDS (38%) and liver disease (22%) among HIV-HBV co-infected patients. Liver disease was a more frequent cause of death among patients co-infected by both HCV and HBV (44% of cases). Hepatocellular carcinoma was present in 15% of patients who died from liver disease, and was associated with HBV co-infection. Nearly half the patients who died from liver disease had more than 200 CD4/mm3. Conclusions: Liver disease is now a leading cause of death among HIV-HCV co-infected patients and is becoming an important cause of death among HIV-HBV co-infected patients. The risk of death from liver disease is highest in patients co-infected by both HCV and HBV. [Copyright &y& Elsevier]
- Subjects :
- *LIVER diseases
*HIV-positive persons
*HEPATITIS C
*LIVER cancer
Subjects
Details
- Language :
- English
- ISSN :
- 01688278
- Volume :
- 42
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 17810689
- Full Text :
- https://doi.org/10.1016/j.jhep.2005.01.022