Back to Search
Start Over
Synthesis, characterization, antibacterial efficacy, and Cytotoxicity of monoclinic KMg3(Al0.5B0.5)Si3O10F2: A novel material for anticariogenic applications.
- Source :
-
Ceramics International . Sep2024:Part B, Vol. 50 Issue 17, p30658-30669. 12p. - Publication Year :
- 2024
-
Abstract
- Fluorophlogopite is a well-known fluorosilicate glass-ceramic derivative known for its bioactivity, machinability and optimal mechanical properties. There is limited information regarding its antibacterial and biocompatible properties. This research paper presents the synthesis and characterization of a novel Boron-doped Fluorphlogopite [KMg 3 (Al 0.5 B 0.5)Si 3 O 10 F 2 ] aiming to improve its antibacterial properties intended for anticariogenic applications. The combustion synthesis method was employed, with oxalyl dihydrazide (ODH) (C 2 H 6 N 4 O 2) serving as the fuel. X-ray Diffraction (XRD) analyses unveiled a monoclinic crystal system, showcasing a P2 1 space group, and an average crystallite size of approximately 28 nm. Morphological scrutiny divulged clustered, irregularly shaped, cluster-like structures. The energy gap was determined to be around 4.97 ± 0.0062 eV. Fourier-Transform Infrared (FTIR) spectroscopy depicted the presence of characteristic bonds. BET analysis indicated the presence of a large surface area and porous structure (mesopores), which may contribute to lower MIC and MBC values, enhancing antibacterial effectiveness. The antibacterial activity, evaluated via agar well diffusion, yielded an 8 mm zone of inhibition. Furthermore, the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) against S mutans were determined to be 2 mg/ml and 16 mg/ml, respectively. The biocompatibility of the synthesized KMg 3 (Al 0.5 B 0.5)Si 3 O 10 F 2 was assessed through the MTT assay, indicating non-toxic behavior at a concentration of 12 μg/ml with 98 % cell viability, while showing moderate toxicity with 61 % viable cells at its highest concentration of 200 μg/ml. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02728842
- Volume :
- 50
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Ceramics International
- Publication Type :
- Academic Journal
- Accession number :
- 178090953
- Full Text :
- https://doi.org/10.1016/j.ceramint.2024.05.366